Immediate comparison of targeted MRI-guided biopsy with systematic transrectal ultrasound guided biopsy in patients with previous negative prostate biopsies

Zielsetzung: To directly compare the diagnostic performance of targeted MRI-guided biopsy (MR-GB) and systematic transrectal ultrasound guided biopsy (TRUS-GB). Material und Methodik: 35 patients with at least one negative TRUS-GB, persistently elevated or rising PSA and a lesion suspicious for prostate cancer (PCa) on 1.5 endorectal coil MRI or 3.0 Tesla MRI were included. In median two targeted biopsies per suspicious lesion on MRI were obtained, systematic TRUS-GB was performed subsequently by an independent urologist without knowledge of the MRI findings. Definite pathology reports were analyzed for anatomic…