T2- and diffusion-weighted MR imaging to assess primary Gleason grade of prostate cancer

Whether combination of T2 signal intensity (SI) and apparent diffusion coefficient (ADC) allows for enhanced discrimination of Gleason scores (GS) in prostate cancer (PCA). Whether ADC allows for a discrimination of primary Gleason grade in patients with GS 7. In step-sectioned prostatectomy specimens, 104 PCA foci of 66 patients were identified and graded according to the modified GS system. MR SI of prostate tumors standardized to obturator muscle (T2R Tm, ADC Tm, proposed ADC/T2R ratio) and relation to GS were tested using multivariate analysis with generalized estimation equations. Diagnostic accuracy was as…