The MLL recombinome

We have investigated MLL rearranged leukemia cases (n = 1590) and present the latest update on this disease entity. About 80 direct MLL fusions and more than 120 reciprocal MLL fusions have been characterized. All patients were classified according to age (infants, pediatric, adult) and their disease phenotype (ALL, AML, others). Of interest, there are significant differences in the MLL breakpoint distribution that allows to draw conclusions about the biology of MLL fusion proteins. Breakpoints in the MLL breakpoint cluster define distinct functions the resulting fusion proteins. Moreover, we will propose a mole…