CareLit Fachartikel

A role for Dual Specificity Phosphatase 6 (DUSP6) in the propagation and self-renewal of Acute Myeloid Leukaemia (AML)

L McKenzie, N Martinez-Soria, C Bonifer, O Heidenreich · Klinische Pädiatrie · 2014 · Heft 05

Dokument
984306
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
L McKenzie, N Martinez-Soria, C Bonifer, O Heidenreich
Ausgabe
Heft 05 / 2014
Seiten
–
Erschienen: 2014-05-12 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0034-1374833

Zusammenfassung

Chromosomal rearrangements are commonly associated with AML. The translocation t(8;21) is the most common rearrangement, found in 10 – 15% of AML and generates the RUNX1/ETO (AML1/ETO, RUNX1/RUNX1T1) fusion protein. A dynamic equilibrium between RUNX1 and RUNX1/ETO binding is required for maintaining the leukaemic phenotype. In spite of being a transcriptional repressor, RNAi experiments identified many direct RUNX1/ETO target genes that are upregulated by this fusion protein including DUPS6 and PTK2. PTK2 encodes the Focal Adhesion Kinase (FAK) which regulates cell proliferation and migration. DUSP6 (MKP3) also…

Schlagworte

Dusp6 Runx1 Protein Proliferation Propagation Self-Renewal Fusion Kinase Cells Specificity Phosphatase Acute Klinische Pädiatrie