Fibroblast growth factor receptors as therapeutic targets in neuroblastoma
E Arnz, F Hertwig, A Krämer, F Ikram, F Roels, H Kocak, A Engesser, R Thomas, M Peifer, S Ackermann, M Fischer · Klinische Pädiatrie · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
To identify progression-driving molecular alterations in neuroblastoma, we used DNA deep-sequencing of 213 primary tumors, RNA deep-sequencing of 498 primary tumors, and microarray gene expression analysis of 709 tumors. While a heterogeneous mutation spectrum was observed in general, we identified putatively activating mutations in fibroblast growth factor receptor (FGFR) tyrosine kinase genes in several cases of high-risk neuroblastoma patients. In addition, gene expression data suggest that elevated FGFR expression in neuroblastoma is associated with a poor patient outcome, suggesting that FGFR may represent…
