Analysis of mRNA-expression profiles of GRB14 in human subcutaneous and visceral adipose tissue
T Wohland, D Schleinitz, M Kern, M Prellberg, J Breitfeld, N Klöting, M Stumvoll, M Blüher, P Kovacs · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: The GRB14 locus (Growth Factor Receptor-Bound Protein 14) has been shown to be associated with waist to hip ratio (WHR). To investigate possible mechanisms explaining the association, we assessed the relationship between the WHR-associated single nucleotide polymorphism (SNP) rs10195252, adipose tissue (AT) GRB14 mRNA expression and metabolic traits related to fat distribution (FD) Methods: mRNA-expression of GRB14 was measured in 620 paired samples of human subcutaneous (SAT) and visceral AT (VAT) by real-time PCR. Genotyping of rs10195252 was done by employing the TaqMan technique. Relationships bet…
