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Regulation of thioredoxin interacting protein by FFA1 ligands under hyperglycemic conditions

M Panse, G Kaiser, F Gerst, HU Häring, S Ullrich · Diabetologie und Stoffwechsel · 2014 · Heft 05

Dokument
984319
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
M Panse, G Kaiser, F Gerst, HU Häring, S Ullrich
Ausgabe
Heft 05 / 2014
Seiten
–
Erschienen: 2014-05-06 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0034-1374963

Zusammenfassung

Background and aim: Multiple observations suggest that glucose-dependent stimulation of thioredoxin interacting protein (TxNIP) expression contributes to glucotoxicity. TxNIP inhibits thioredoxin thereby increasing the mitochondrial oxidative stress. TxNIP is transcriptionally activated by ChREBP, while FOXO1 antagonizes ChREBP binding to the TxNIP promoter. Glucose increases nuclear accumulation of ChREBP. Palmitic acid, a ligand for free fatty acid receptor-1 (FFA1), activates FOXO1 in a PKCdelta-dependent manner and has been found to inhibit TxNIP expression. Previously, we observed that a synthetic agonist f…

Schlagworte

Txnip Foxo1 Expression Tug-469 Nuclear Accumulation Pkcdelta Thioredoxin Protein Chrebp Palmitic Cells Diabetologie und Stoffwechsel