L-serine supplementation suppresses the formaiton of neurotoxic deoxysphingolipids and improves neuropathy in a type 1 diabetic rat model
T Hornemann, A Othman, A von Eckardstein, C Porretta-Serapiglia, G Lauria, R Bianchi · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
1-Deoxyceramides (deoxyCer) are atypical ceramides which are formed by the enzyme serine-palmitoyltransferase (SPT) due to a promiscuous use of L-alanine over its canonical substrate L-serine. DeoxyCer are neurotoxic and induce neurite retraction in cultured primary neurons. Pathologically increased deoxyCer levels cause HSAN1, an inherited axonal neuropathy which is associated with several missense mutations in SPT. Also patients with type 2 diabetes (T2DM) have significantly elevated deoxyCer plasma levels suggesting that these lipids are also involved in the pathology of the diabetic sensory neuropathy (DSN).…
