CareLit Fachartikel
Analysis of parent of origin effects in Sorbs using long range phasing algorithms
X Liu, M Scholz, A Tönjes, M Stumvoll, PF Stadler, Y Böttcher · Diabetologie und Stoffwechsel · 2014 · Heft 05
Dokument
984326
CareLit-ID
Jahr
2014
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Background and aim: Genome-Wide Association Studies (GWAS) were successfully applied to discover associations between genetic variation and Body Mass Index (BMI). However inheritance in terms of phase is limited in GWAS. The analysis of GWAS considering parental inheritance will provide further insights into the genetic mechanisms contributing to obesity. We hypothesized there may be genetic variances having different effect sizes for obesity depending on the transmission from father or mother. Material and methods: Genome-wide genotypes (Affymetrix 500K and 6.0) and family information from the Sorbs population…
Schlagworte
Association
Alleles
Obesity
Algorithms
Adipocytes
Population
Diabetologie und Stoffwechsel
