Type 2 Diabetes mellitus genetic risk variant T in TCF7L2 rs 7903146 in women is associated with an increased risk for the development of gestational diabetes mellitus (GDM) with…
L Potasso, N Perakakis, A Lamprinou, E Polyzou, D Kassanos, A Peter, R Rasenack, G Päth, J Seufert, K Laubner · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Objective: Single nucleotide polymorphisms (SNPs) within the transcription factor 7-like 2 (TCF7L2) gene are recognized risk variants for type 2 diabetes (T2D). The aim of this international multicentric analysis was to evaluate the effect of the T risk variant rs7903146 on the development and clinical course of GDM. Material and methods: We genotyped the TCF7L2 rs7903146 C/T polymorphism in 150 women with a history of GDM (Greek n = 50, German n = 100) and in 160 non-diabetic pregnant women (Greek n = 81, German n = 79). The prevalence of wild-type and risk TT alleles was com ared in combined and separate count…
