Combined faecal quantitative calprotectin and immunochemical faecal occult blood tests for the detection of colorectal carcinoma and significant adenomas

Introduction: Testing for faecal occult blood is a widely accepted non-invasive screening method for colorectal cancer (CRC) and significant adenomas, but lack of sensitivity remains a critical problem. The aim of this study was to analyze the combined sensitivity and specificity of faecal quantitative calprotectin and immunochemical faecal occult blood tests in patients with colorectal cancer and colonic polyps. Methods: We prospectively tested a combination of faecal tests [immunochemical faecal occult blood test (i-FOBT) and quantitative calprotectin (QC)] as biomarkers for advanced colorectal neoplasia (adva…