Effects of hydrogen sulphide on heme oxigenase activity in TNBS induced colitis
K Kupai, Z Szalai, M Korsós, Z Baráth, S Török, R Szabó, A Csonka, L Daruka, A Pósa, C Varga · Zeitschrift für Gastroenterologie · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Hydrogen sulfide (H2S) is an endogenous mediator that relaxes vascular smooth muscle, exhibits several antiinflammatory activities and contributes to protection. Specially, we investigated the beneficial effects of H2S and whether heme-oxigenases (HO) are involved in the H2S-induced colonal cytoprotection against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. Male Wistar rats were treated with TNBS (10 mg) to induce colitis. H2S donor (Lawesson's reagent) were used at different concentrations (60; 30; 15; 7.5; 3.75; 1.87;0.93µM; dissolved in carboxymethylcellulose twice daily per os (from 0 d…
