Investigating the role of BAFF in different mouse models of allergic asthma
A Lorenz, M Busse, K Dalüge, AK Behrendt, G Hansen, A Meyer-Bahlburg · Pneumologie · 2014 · Heft 06
Bibliografische Angaben
Zusammenfassung
*equal contribution Introduction: The cytokine B cell activating factor of the TNF family (BAFF) is crucial for the homeostatic development, differentiation and proliferation of B cells in the periphery. It is well known that elevated BAFF levels are associated with autoimmune diseases but its role in allergic diseases including asthma is barely understood. Aims and objectives: To better comprehend the role of BAFF in allergic asthma we started analyzing BAFF in murine asthma models. Methods: Wildtype (WT) and B cell deficient (µMT) mice were immunized with ovalbumin (OVA) or house dust mite (HDM). Bronchoalveol…