Epigenetic modulation of cancer cells by natural polyphenols and flavonoids

Introduction: A variety of natural compounds, especially polyphenols and flavonoids, display interesting beneficial physiological activities. Some specific compounds show promising chemopreventive and anticancer activities even against therapy-resistant malignancies like hepatocellular carcinomas (HCC). The aim of this study was to analyze a possible epigenetic modulation of tumor cells by particular polyphenols and flavonoids that exhibit a broad anticancer activity. Methods: Different chemical groups of polyphenols and flavonoids were examined in silico by docking analyses, in vitro by assaying viability, prol…