Changes of gene expression of different BMP-proteins in liver in different mouse and rat models of acute phase reaction

Background and Aim: Hepcidin has been considered to have a pivotal role in regulating hepatic iron metabolism. Recently proteins of the TGF-family, manly BMP-4, BMP-6 and BMP-9 have been attributed an additional role in iron metabolism control. As hepcidin is a positive acute phase protein, we aimed to study changes of gene expression of BMPs in two murine models of acute phase reaction (APR), to individuate the main cellular source of BMP-6 in the liver and to determine the role of IL-6 on BMPs gene expression using mice knock out for IL-6. Methods: Wild type and IL-6 ko-mice were treated either with turpentine…