Expression of progesterone receptor membrane component 1 (PGRMC1) in tissues of breast cancer patients

Progesterone receptor membrane component 1 (PGRMC1) may be important in tumorigenesis and thus may increase the risk for developing breast cancer under certain circumstances e.g. during hormone therapy. The main purpose of this study was to investigate the expression of PGRMC1 in benign and malignant tissues of breast cancer patients. Matching 'baseline' tissue biopsies of 69 breast cancer patients undergoing neoadjuvant therapy were analyzed by immunohistochemistry for expression levels of PGRMC1 and its phosphorylated version at serine 180. Associations with clinicopathological parameters, e.g. tumour grading…