Tumor biology driven treatment selection in primary ovarian cancer
F Arnold, D Margraf, O Hoffmann, K von Dehn-Rotfelser, I Funke, R Loewe, A Burges, D Beer, J Werner, B Mayer · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09
Bibliografische Angaben
Zusammenfassung
Rationale: Primary ovarian cancer initially represents a chemosensitive tumor type. However, a considerable number of the patients suffer relapse following adjuvant platinum based therapy. Both, intrinsic and acquired drug resistance mechanisms are involved. In the present study various tumor biologic characteristics mediating drug resistance were elucidated and integrated in the therapeutic management of primary ovarian cancer. Patient and methods: Fresh tumor samples were obtained from 45 primary ovarian cancer patients. Frozen sections were prepared and analysed for drug resistance markers with qPCR. Leukocyt…
