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Variable FMR1 gene expression in human granulosa cells depending on FSH stimulation

D Alcoba, J Dietrich, I Brum, T Strowitzki, P Vogt, J Rehnitz · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09

Dokument
984750
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
D Alcoba, J Dietrich, I Brum, T Strowitzki, P Vogt, J Rehnitz
Ausgabe
Heft 09 / 2014
Seiten
–
Erschienen: 2014-09-05 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0034-1388543

Zusammenfassung

Introduction: The FMR1 gene (Fragile X Mental Retardation 1) and its protein (FMRP) are expressed in granulosa cells of human folliculogenesis probably involved in translation control during oocyte maturation. FSH is an important factor to stimulate granulosa cell proliferation/differentiation at antral phase. Question of the study: Pilot study aimed to evaluate gene expression of FMR1 in primary granulosa cell cultures in comparison to a granulosa cellular model system (COV4343) whether depending on FSH stimulation. Material and methods: RNA from luteinized granulosa cells (after ovarian puncture by IVF techniq…

Schlagworte

Geburtshilfe und Frauenheilkunde