Predictors of survival after surgery among patients with large cell neuroendocrine carcinoma of the lung

Objective: Large cell neuroendocrine carcinoma (LCNEC) represents a rare entity in non-small cell lung cancer with only partially understood biology and poor survival. Diagnosis is difficult to obtain based on small biopsies but surgical resection may be indicated only in a small fraction of patients. Aim of the study was to assess clinical characteristics, immunohistochemical features and surgical outcomes of patients with LCNEC in order to identify predictors regarding outcome and long-term survival. Materials and methods: Clinical data of 57 patients with surgically resected LCNEC between march 2003 and decem…