A translational journey in Germany: From literature to local implementation of [89Zr]Zr-DFO-trastuzumab
Joana do Mar Ferreira Machado, Kristof Zarschler, Torsten Knieß, Martin Kreller, Matthias Miederer, Florian Brandt, Rudi Apolle, Theresa Link, Robert Winzer, Pauline Wimberger, Klaus Kopka, Oliver Kiß · Nuklearmedizin - NuclearMedicine · 2026 · Heft 04 · S. 265-270
Bibliografische Angaben
Zusammenfassung
Abstract Aim [⁸⁹Zr]Zr-DFO-trastuzumab has emerged as a powerful tool to visualise non-invasively HER2 expression across metastatic lesions, complementing conventional pathological HER2 evaluation and helping to identify patients unlikely to benefit from therapy with trastuzumab-based therapies. This paper outlines the roadmap of the manufacturing implementation of [89Zr]Zr-DFO-trastuzumab at our centre in Germany. Methods In this paper, we describe the key questions encountered during implementation of the manufacturing process for [89Zr]Zr-DFO-trastuzumab and how these were addressed through discussions between…
