Early on-treatment HDV-RNA kinetics are not predictive for long-term response to a PEG-IFNa therapy of hepatitis delta
M Wöbse, C Yurdaydin, S Ernst, S Hardtke, B Heidrich, B Bremer, O Keskin, R Idilman, A Koch, MP Manns, H Wedemeyer · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: PEG-Interferon alfa (PEG-IFNa) is the only currently available treatment option for hepatitis delta. One main goal of therapy is sustained HDV-RNA suppression which is achieved in less than 30% of cases. In PEG-IFNa therapy of HCV infection, early viral kinetics have high positive and negative predictive values for SVR, allowing individualization of treatment. Similar data are not available for HDV infection. Aims: Analysis of early HDV-RNA kinetics during PEG-IFNa therapy of hepatitis delta to establish stopping rules to avoid unnecessary treatment. Methods: In the HIDIT-2 study 120 HDV-RNA-positi…
