Phenprocoumon-induced liver injury

Introduction: Phenprocoumon (Marcumar®), a derivative of 4-hydroxycoumarin with similarity to warfarin, is the most frequently used oral anticoagulant drug in continental europe. Apart from bleeding disorders, other adverse reactions are rare due to its mechanism of action. In the last years, hepatotoxicity has been observed and several case reports have been published. Yet, so far, no systematic analyses of this potentially life-threatening complication have been performed. Material & Methods: We analysed the clinical presentation and the liver histology of 53 patients with hepatic disease of unknown origin, wh…