Loss of cell polarity defines a cancer-prone phenotype in liver epithelial cells
S Wan, AS Meyer, S Weiler, T Lutz, S Rössler, C Rupp, P Schirmacher, F Pinna, K Breuhahn · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background/Aims: Loss of cell polarity has been shown to play an essential role in the cause and progression of carcinogenesis in cells of epithelial origin. Three polarity protein systems (PPS) are involved in the acquisition and maintenance of cell polarity: the apical Crumbs complex(Crumbs, Pals1,PatJ), the subapical Par complex(Par6, Par3,aPKC), and the basolateral Scribble complex(Lgl1/2, Dlg1, Scribble). It is now well accepted that the Hippo pathway and its transcriptional co-activators yes-associated protein (YAP)/TAZ (WWTR1) are well connected to PPS via partly unknown mechanisms. In this project we aim…
