Identification of critical intersections points for M1 and M2 differentiation of macrophages by a systems biology approach

Objectives: Macrophages are cells with remarkable plasticity. They are able to integrate signals from their microenvironment leading to context dependent differentiation into classically activated macrophages (M1) or alternatively activated macrophages (M2). Within the liver, macrophages are known to mediate important hepatoprotective and pro-regenerative effects but may also be responsible for impaired hepatocyte function and liver injury in response to microbial pathogens. The mechanisms responsible for this controversial role of liver macrophages are still incompletely understood. Methods and Results: Within…