Serum biomarker profile can predict the outcome of acute HCV infection

Introduction: The natural course of acute hepatitis C virus infection is highly diverse varying between spontaneous clearance of the virus to evolution of chronic hepatitis C (HCV) virus infection. The aim of this study was to identify parameters during early time points of infection predicting the natural course of the infection by analysis of serum IP-10 levels and other cytokines and chemokines thus enabling identification of patients not achieving spontaneous viral clearance who might require antiviral treatment. We performed multianalyte profiling of 50 cytokines and chemokines in the serum using the BioPle…