Volumetric and scintigraphic changes following endoscopic lung volume reduction

Introduction: Endoscopic lung volume reduction (ELVR) is an emerging therapy for emphysematous COPD. While volumetric adaptations following ELVR have reiteratedly been focused on, the interaction of volume and perfusional-ventilatory changes remains undetermined. We therefore took aim at defining the extent of interdependency of ELVR-mediated volumetric and scintigraphic adaptations. Methods: We enrolled 24 patients (64.3 ± 8.8yrs, 58.3% male) with COPD heterogeneous emphysema undergoing ELVR with endobronchial valves (EBV, Zephyr®, Pulmonx, Inc.). Mean baseline FEV1 and RV were 32.9% and 256.0% predicted, respe…