Reduced urinary aldosterone in preeclampsia, superimposed pre-eclampsia compared to standard- and high-risk pregnant women

Background: Women with chronic kidney disease (CKD) and chronic hypertension (CHT) are at increased risk of superimposed pre-eclampsia (SPE) and associated adverse pregnancy outcomes. Diagnosis of SPE using blood pressure and proteinuria is of limited use because they may develop in women with CKD or CHT without the condition. Inaccurate diagnosis may result in unnecessary iatrogenic preterm delivery. In established pre-clampsia (PE), aldosterone levels are supressed. The aim of the study was to compare the urinary aldosterone concentrations between normotensive controls (NC), PE and CKD/CHT women with and witho…