The role of VEGFA in regulation of fat distribution
J Krüger, M Quandt, B Gutsmann, D Schleinitz, J Breitfeld, M Kern, N Klöting, A Tönjes, M Blüher, M Stumvoll, P Kovacs · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: Body fat distribution as one of the main predictors of obesity associated complication is controlled by genetic factors. Polymorphisms in the vascular endothelial growth factor A (VEGFA) have been shown to be associated with waist to hip ratio (WHR) in recent genome-wide association studies. We tested the hypothesis that VEGFA is involved in the control of fat distribution and its expression correlates with obesity related traits. Material and methods: We measured the mRNA levels of VEGFA in paired human samples of visceral and subcutaneous adipose tissue from 570 individuals with detailed metabolic…
