Genome-wide association study suggests novel loci involved in the regulation of circulating BMP2 levels
T Wohland, M Unthan, M Scholz, D Schleinitz, M Quandt, M Stumvoll, A Tönjes, P Kovacs · Diabetologie und Stoffwechsel · 2015 · Heft 04
Bibliografische Angaben
Zusammenfassung
Aims: The Bone Morphogenetic Protein 2 (BMP-2) is a key player in the development of the postnatal skeleton and may be involved in the regulation of adipogenesis and pancreatic ß-cell development. Our preliminary data show clear relationship between BMP2 and traits related to obesity. However, genetic factors determining the variability in circulating BMP2 levels are yet unknown. We therefore conducted a genome-wide association study (GWAS) for serum BMP2. Subjects and methods: We measured circulating BMP2 by ELISA (Cloud- Clone- Corp.) in 638 serum samples derived from the previously recruited and phenotypicall…
