Bilateral diffuse pseudoangiomatous stromal hyperplasia (PASH) causing gigantomastia in a 33-year-old pregnant woman: case report

Pseudoangiomatous stromal hyperplasia (PASH) is a benign proliferation of mammary stroma mostly described as incidental microscopic finding. It can clinically manifest as a palpable, well circumscribed breast mass or in rare cases as a diffuse bilateral process causing massive breast enlargement. The most postulated theory for aetiology of this condition is hormonal stimulation of mammary miofibroblast, particularly by progesterone. The definite diagnosis of PASH is based on typical pathological findings like stromal hyperplasia and empty slitlike channels positive for myofibroblastic and negative for endothelia…