Possible role of estrogen receptor-alpha in the signaling mechanism of progesterone receptor membrane component-1 in human breast cancer

Einleitung/Zielsetzung: Hormone therapy (HT) is commonly recommended clinically to relieve postmenopausal symptoms. Since the early 1940 s, when estrogen was introduced into clinical practice, there were concerns that HT may cause breast cancer. Research data from our laboratory suggest that a signaling pathway activated via progesterone receptor membrane component 1 (PGRMC1) may be important in terms of HT related breast cancer risk. Material & Methoden: MCF-7 and T47D cells were stably transfected with PGRMC1 and mutants thereof. In the present work, the influence of different inactivated PGRMC1 phosphorylatio…