Disturbed energy metabolism and lipid profile after a 4 week high oral fructose challenge: potential role of bile acids?

Background and Aims: Fructose overconsumption is linked to non-alcoholic fatty liver disease and impaired lipid and glucose metabolism. Since bile acids (BA) are critical regulators of lipid and energy metabolism, we aimed to explore whether dietary fructose challenge (FC; 150 g/day for 4 weeks) may impact on lipid and glucose dysbalance by changing BA metabolism. Methods: Ten healthy volunteers were enrolled (m: f = 5: 5; age = 24.5 [21 – 37]). Blood was collected prior and after FC for routine laboratory analysis, BA and lipid profiling. Hepatic fat content was measured using magnetic-resonance-spectroscopy (M…