The presence of a PNPLA3 (rs738409) single nucleotide polymorphism (SNP) is not associated with increased risk for fibrosis, portal hypertension, and hepatic steatosis in HIV/HCV-…
B Scheiner, M Mandorfer, P Schwabl, B Payer, M Aichelburg, K Grabmeier-Pfistershammer, A Stättermayer, P Ferenci, M Trauner, M Peck-Radosavljevic, T Reiberger · Zeitschrift für Gastroenterologie · 2015 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background and aims: HIV/HCV-coinfected patients often show hepatic steatosis, faster fibrosis progression, and a higher risk of developing end-stage liver disease. While several risk factors for faster fibrosis progression have been established, the role of a genetic variation of the patatin-like phospholipase domain-containing protein 3 (PNPLA3) remains unclear. Thus, we examined the impact of the PNPLA3 single nucleotide polymorphism (SNP rs738409) on liver steatosis and fibrosis in a cohort of HIV/HCV-coinfected patients. Methods: 177 HIV/HCV-coinfected patients with available data on PNPLA3 (SNP rs738409) a…
