Priming of inflammatory cells with NOTCH ligands stimulates migration

The NOTCH pathway is a well-conserved signaling pathway that is believed to be engaged in several pathological processes in the lung, e.g. pulmonary arterial hypertension (PAH). In PAH it has been shown that a significant increase of perivascular numbers of inflammatory cells occurs. Is NOTCH activation involved in their recruitment? The aim of this study was to elucidate the role of the NOTCH signaling pathway in inducing migration of inflammatory cells by priming cells with Jagged-1 and Delta like-4. Human monocytes, T-lymphocytes and dendritic cells were isolated from venous blood from healthy volunteers. For…