Modeling of TGFb pathway dynamics in lung cancer cells

Rationale: Transforming growth factor-β (TGFβ)-induced effects are different, even opposite, depending on the cellular type and conditions. TGFβ signaling has been widely acknowledged to contribute to cancerogenesis via enhancing tumor cell metastasis. Numerous attempts to target TGFβ pathway to reduce cancer spread proved to be ineffective. Aim: In the current work we aim to use systems biology approach in order to obtain better understanding of information processing in TGFβ/Smad signaling pathway. Identifying emerging systems-level properties that arise from network components would help discovering novel the…