Treatment-Adjusted Cross-Sectional Associations of Serum Calprotectin, Sialic Acid, and Pannexin-1 with Interstitial Lung Disease in Treated Rheumatoid Arthritis
Burcu Güneş Alpaydın, I. Merve Uçar Baytaroğlu, Gokhan Sargin, Ayça Tuzcu, Songül Çildağ, Taşkın Şentürk · Aktuelle Rheumatologie · 2026 · Heft 09
Bibliografische Angaben
Zusammenfassung
Abstract Objective Most RA-ILD biomarker studies enroll patients receiving treatment, which may alter inflammatory activity. We investigated whether calprotectin, sialic acid, and pannexin-1 show treatment-adjusted cross-sectional associations with ILD status in patients receiving treatment for RA. Methods This cross-sectional case-control study included 154 participants (49 patients with HRCT-confirmed RA-ILD, 55 RA patients without ILD, 50 healthy controls). Serum biomarkers were measured by ELISA. The primary multivariate logistic regression model for ILD status within the RA cohort was adjusted for age, sex,…
