The pancreatic cancer risk variant rs3790844 of the nuclear receptor NR5A2 modulates genetic susceptibility of cholangiocarcinoma

Background: There is limited information on risk factors modulating genetic susceptibility to cholangiocarcinoma (CCA), the second most common primary liver cancer fraught with a poor prognosis and ill-defined pathogenesis.[1] A common variant in the liver receptor homologe-1 (LRH-1) gene, alternatively referred to as NR5A2, has been identified as a genetic risk factor for pancreatic cancer.[2] Since the nuclear receptor (NR) 5A2 is critically involved in embryonic development, bile salt metabolism and cholesterol transport, we assessed a potential contribution of rs3790844 in genetic CCA risk.[3] Patients & Met…