IgG- and IgM-antibodies against HLA are associated with allograft dysfunction after lung transplantation

Introduction: The aim of our study was to investigate the clinical relevance of IgG-and IgM-antibodies (ab) against HLA on chronic lung allograft dysfunction (CLAD) in lung transplant recipients. Methods: We performed a study of 120 lung transplant recipients transplanted between 2007 and 2011. Patient sera were investigated before and after transplantation. The sera were screened and specified by means of Luminex® and CDC for IgG- and IgM-ab. Outcome parameters were bronchiolitis obliterans syndrome (BOS) and survival. Results: Preformed HLA-IgG-ab were detected in 19/120 (15.8%) and IgM-ab in 9/120 (7.5%). In…