Peculiar Fibronectin immunohistochemical staining in placental tissue of pathological pregnancies associated with insufficient placentation

Objective: To investigate the role of Fibronectin, an extracellular matrix protein essential in the process of trophoblastic invasion, in the development of pregnancy-related pathologies associated with insufficient placentation. Materials and methods: Retrospective study including 36 early (< 34th gestational age) preeclampsia (PE), 14 late (≥34th gestational age) PE, 6 HELLP syndrome (hemolysis, elevated liver enzymes, low platelet count), 18 small for gestational age (SGA) fetuses (under the 10th percentile), 17 early intrauterine growth restriction (IUGR), 35 late IUGR, and 64 controls. Fibronectin localizat…