Fibrosis regression in autoimmune hepatitis

Background: A primary objective of immunosuppressive therapy in autoimmune hepatitis (AIH) is to prevent the progression of liver fibrosis. In patients with viral hepatitis it is now accepted that after control of the virus fibrosis may regress, even in patients with prior liver cirrhosis. Aims: to assess changes of liver fibrosis in AIH patients over time by using transient elastography (TE) and liver biopsy. In addition, we compared fibrosis development in AIH with the development in primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). Methods: In a pilot study we validated the diagnostic…