Differential modulation of vesicular and non-vesicular associated microRNAs isolated from sera of partially hepatectomized rats

Cell-free circulating microRNAs are protected from degradation by their association with either component of the RNAi machinery or vesicles. Although increasing evidences shows that different types of vesicles are capable of transporting microRNAs, current research mainly focuses on the characterization of exosomal microRNAs. Reason for this is that exosomal-microRNAs are thought to directly participate in intercellular communication. However, is yet unclear whether exosomal-microRNAs are also the most reliable source for discovering disease-associated biomarker. In this study, the distribution of circulating mi…