The platelet-derived chemokine CXCL4 exerts protective role in non-alcoholic steatohepatitis (NASH) in vivo
HK Drescher, C Berger, P Fischer, ML Berres, DC Kroy, KL Streetz, C Trautwein, H Sahin · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Introduction: Non-alcoholic steatohepatitis (NASH) is the third most common reason for liver transplantations in developing countries and one of the fastest growing medical problems. Aim: It is known that platelets are involved in non-alcoholic fatty liver disease. The significance of CXCL4, one of the most abundant chemokines in platelets, in NASH development and progression remains unclear. We therefore investigated the role of CXCL4, also known as platelet factor 4 (PF4), in a high fat (HF) induced NASH mouse model. Methods: Constitutive CXCL4 knockout mice were fed HF-diet for 14 weeks. Results: After 14 wee…
