A steatotic environment promotes the progression of hepatocellular carcinoma via direct and indirect mechanisms
A Koch, A Mahli, SM Lee, WE Thasler, A Hartmann, M Müller, AK Bosserhoff, C Hellerbrand · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
The metabolic syndrome and hepatic steatosis are independent risk factors for the progression of hepatocellular carcinoma (HCC). Still, the underlying mechanisms are only incompletely understood. The aim of this study was to analyze the influence of a steatotic environment on HCC cells in vitro, in a syngeneic orthotopic murine HCC model and in clinical HCC samples. Methods and Results: Murine Hepa129 HCC cells were implanted into the liver of C3 H/HeN control mice or mice fed with a high-fat diet (HFD). Until then, the HFD had caused obesity and hyperlipidemia as well as significant hepatic steatosis but no inf…
