Wisp1 as an early stage marker of human hepatocellular carcinoma (HCC)?
A Dropmann, T Feng, T Dediulia, I Ilkavets, B Hofmann, H Weng, A Piiper, O Waidmann, L Quagliata, M Matter, S Dooley, N Meindl-Beinker · Zeitschrift für Gastroenterologie · 2015 · Heft 12
Bibliografische Angaben
Zusammenfassung
Background and aims: Microarray analysis of TGF-β treated mouse hepatocytes revealed Wisp1 as the most regulated gene. As TGF-β is upregulated during HCC development and progression, we analyzed Wisp1 expression and function in HCC. Methods: Wisp1 mRNA expression was analyzed in 7 publically available HCC patient cohorts. Wisp1 protein expression was determined in patients' serum and liver tissue (46 paired and tissue microarray (TMA) with 220 independent samples) and correlated with clinical parameters and survival. Functional evaluation was performed after Wisp1 overexpression and TGF-β treatment using HuH7 ce…
