Fatty liver reduction and diminished lipolysis by high-protein intake without caloric restriction: a randomized controlled trial in type 2 diabetes

Background and aims: There is lacking data on influence of high-protein diets and protein origin on liver fat content. In our clinical study we compared two different isocaloric high-protein diets of animal (AP) and plant (PP) origin and evaluated changes of body composition and intrahepatic lipid content (IHL) in diabetic subjects. Study design: 37 individuals with type 2 diabetes (age 64 ± 6 years, BMI 30.2 ± 3.6 kg/m2, HbA1c 7.0 ± 0.6%) were randomized to either high-animal protein or high-plant protein diet (30% protein, 40% carbohydrates, 30% fat) for 6 weeks. Before and after diet intervention magnetic res…