Immunohistochemical analysis of CD138-positive Plasma cells in the endometrium

Background: Chronic endometritis is often mild, characterized by the infiltration of plasma cells in the endometrium and usually caused by bacteria. It may be a reason for recurrent miscarriage (RM) and repeated implantation failure (RIF). The aim of this study was to quantify plasma cell concentration in the endometrium of RM and RIF patients. Methods: Endometrial biopsies from 450 patients (232 RIF, 70 RM, 151 unknown reason of infertility) were investigated via immunohistochemistry using DAB staining of CD138+ plasma cells. A second analysis was performed in 15 patients after antibiotic-therapy. ≤3 plasma cel…