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Tetraspanin 7 is a novel autoantigen in type 1 diabetes

D Walther, A Eugster, S Jergens, A Gavrisan, C Weinzerl, T Telieps, C Winkler, AG Ziegler, E Bonifacio · Diabetologie und Stoffwechsel · 2016 · Heft 06

Dokument
987835
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Jahr
2016
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
D Walther, A Eugster, S Jergens, A Gavrisan, C Weinzerl, T Telieps, C Winkler, AG Ziegler, E Bonifacio
Ausgabe
Heft 06 / 2016
Seiten
–
Erschienen: 2016-06-27 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0036-1584103

Zusammenfassung

Autoantibodies to pancreatic beta cell proteins are makers of asymptomatic type 1 diabetes. Tetraspanin 7 is a 38 kDa beta cell glycoprotein that is a candidate target of GLIMA autoantibodies. The aim was to determine whether tetraspanin 7 is a novel autoantibody in early type 1 diabetes. Full length and external domain fragments of tetraspanin 7 were expressed as luciferase-tagged fusion proteins, and used in immunoprecipitation assays to measure autoantibodies in samples from 363 patients with type 1 diabetes at onset of disease, 503 beta cell autoantibody negative first degree relatives of patients, and 212 r…

Schlagworte

Diabetologie und Stoffwechsel