Sarcoidosis: Novel aspects in genetics and pathogenesis

Sarcoidosis shares parts of its genetic background with distinct clinical phenotypes. Most prominently genes encoding components of the Th1/Th17 signaling pathways are associated with sarcoidosis and other diseases, like psoriasis and Crohn's disease (Fischer et al., 2015). This talk will give an updated overview of shared genetic factors between sarcoidosis and other genetically connected disorders. The potential functional consequence of the associated variants will be related to the current knowledge on disease pathogenesis and possible clinical implications will be discussed. Reference: [1] Fischer A, Elling…