Vitamin D metabolic chemotyping in patients with chronic liver diseases

Background: Patients with chronic liver diseases (CLD) often have low serum 25-hydroxyvitamin D (25(OH)D) concentrations. The vitamin D receptor is expressed in immune and non-parenchymal liver cells, and 25(OH)D influences defense against bacterial infections and survival in CLD. The role of other vitamin D metabolites remains largely unknown. The aim herein was to quantify multiple, including downstream vitamin D metabolites (the vitamin D "chemotype") in CLD patients. Methods: Overall, we included 86 CLD patients, who we treated with 20,000 IU vitamin D3 weekly for 6 months if they had low vitamin D serum lev…