Crosstalk between Estrogen receptor β and Wnt- Signaling Pathway in Endometrial Cancer

Background: Many mechanisms have been implicated to the tumorgenesis and growth of endometrial cancer (EC) such as aberrations of Wnt-Signaling pathway and estrogen receptors. Many attempts have been made to study different molecules in Wnt- signalling pathway as targets for diagnosis and treatment of EC such as Dickkopf-1 (DKK1) and beta-Catenin proteins. Another widely discussed mechanism is the expression of various estrogen receptors. The expression of estrogen receptor alpha has been well documented in endometrial cancer. Recently estrogen receptor beta and its subtypes have been emerged into focus. The aim…